Fc Glycan-Modulated Immunoglobulin G Effector Functions
نویسندگان
چکیده
منابع مشابه
A common glycan structure on immunoglobulin G for enhancement of effector functions.
Antibodies have been developed as therapeutic agents for the treatment of cancer, infection, and inflammation. In addition to binding activity toward the target, antibodies also exhibit effector-mediated activities through the interaction of the Fc glycan and the Fc receptors on immune cells. To identify the optimal glycan structures for individual antibodies with desired activity, we have deve...
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Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is detected in human sera. Several groups have found global or antigen-specific skewing of IgG glycosylation, for example in autoimmune diseases, viral infections, and alloimmune reactions. The IgG glycoprofiles seem to correlate wi...
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IgG antibodies contain a conserved N-glycosylation site on the Fc domain to which a complex, biantennary glycan is attached. The fine structures of this glycan modulate antibody effector functions by affecting the binding affinity of the Fc to diverse Fc receptor family members. For example, core fucosylation significantly decreases antibody-dependent cellular cytotoxicity (ADCC), whereas termi...
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A heterogeneous group of receptors binding the Fc region of Ig, Fc receptors, provides important links between the cellular and humoral branches ofthe immune system. The members of this receptor group, specific for essentially all the Ig isotypes, are expressed on a variety of cells and mediate multiple important functions. Receptors for IgG (Fc’yR) , a subgroup within the larger group of FcR, ...
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The diversity of immunoglobulin (Ig) functions may be explained by the peculiar structure of these flexible molecules. Heavy and light Ig chains are composed from compact stable immunoglobulin folds (IgF), or domains belonging to a large protein super family. Proteins composed from IgF have been found in various representatives of animal kingdom even those appeared during the very early stages ...
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ژورنال
عنوان ژورنال: Journal of Clinical Immunology
سال: 2014
ISSN: 0271-9142,1573-2592
DOI: 10.1007/s10875-014-0018-3